Gene
clpp
- ID
- ZDB-GENE-030131-7860
- Name
- caseinolytic mitochondrial matrix peptidase proteolytic subunit
- Symbol
- clpp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable ATP-dependent peptidase activity; ATPase binding activity; and serine-type endopeptidase activity. Predicted to be involved in protein quality control for misfolded or incompletely synthesized proteins. Predicted to act upstream of or within proteolysis. Predicted to be part of endopeptidase Clp complex. Is expressed in caudal fin. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112333 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028904Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12373 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Perrault syndrome | Alliance | Perrault syndrome 3 | 614129 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018215 | ClpP, Ser active site |
| Active_site | IPR033135 | ClpP, histidine active site |
| Family | IPR001907 | ATP-dependent Clp protease proteolytic subunit |
| Family | IPR023562 | Clp protease proteolytic subunit /Translocation-enhancing protein TepA |
| Homologous_superfamily | IPR029045 | ClpP/crotonase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent Clp protease proteolytic subunit | ClpP/crotonase-like domain superfamily | ClpP, histidine active site | Clp protease proteolytic subunit /Translocation-enhancing protein TepA | ClpP, Ser active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q502B9 | InterPro | 266 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-204F11 | ||
| Encodes | EST | fj37a05 | ||
| Encodes | cDNA | MGC:112333 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020684 (1) | 1205 nt | ||
| Genomic | GenBank:BX649502 (2) | 247387 nt | ||
| Polypeptide | UniProtKB:Q502B9 (1) | 266 aa |
- Légaré, V.P., Rampal, C.J., Gurberg, T.J.N., Aaltonen, M.J., Janer, A., Zinman, L., Shoubridge, E.A., Armstrong, G.A.B. (2023) Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mitochondrial integrated stress response. Developmental Neurobiology. 83(1-2):54-69
- Wen, W., Guo, C., Chen, Z., Yang, D., Zhu, D., Jing, Q., Zheng, L., Sun, C., Tang, C. (2023) Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. PLoS One. 18:e0294700e0294700
- Wei, B., Zhang, T., Wang, P., Pan, Y., Li, J., Chen, W., Zhang, M., Ji, Q., Wu, W., Lan, L., Gan, J., Yang, C.G. (2022) Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP. Nature communications. 13:6909
- Lin, Y.F., Sam, J., Evans, T. (2021) Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response. iScience. 24:103118
- Chen, D., Zhang, Z., Chen, C., Yao, S., Yang, Q., Li, F., He, X., Ai, C., Wang, M., Guan, M.X. (2019) Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism. Nucleic acids research. 47(10):5341-5355
- Shi, W., Shao, T., Li, J.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 203(9):2425-2442
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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